Mix the cake batter according to directions and than separate into two bowls. Add red & yellow food coloring to one bowl to make orange, and yellow food coloring to the second bowl to make a deeper shade of yellow.
Line the cupcake pan with baking cups and alternate spoonfuls of yellow / orange batter until cups are 2/3 full. Bake cupcakes 12 minutes at 350 degrees, or until a toothpick inserted comes out clean. Set aside and let coo.
Once cupcakes are cooled, mix yellow and red food coloring into vanilla frosting to make orange. Place frosting into a plastic bag and cut off the tip, pipe frosting in a circular motion onto cupcake.
Chop Reese’s Pieces into bits. Top cupcakes with Reese’s Pieces bits or Halloween themed cake topper (skeleton.)